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Professional Summary
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The primary research projects being undertaken in the lab involve those that focus on the mechanisms and consequences of MDMA (Ecstasy)-induced serotonin neurotoxicity. With regard to MDMA neurotoxicity, it is our hypothesis that long term depletion of brain 5-HT occurs as a result of oxidative and/or bioenergetic stress induced by this drug of abuse. Moreover, such long term depletions of brain 5-HT are accompanied by functional consequences evident in disruptions of 5-HT neurotransmission. An additional area of interest is the neuropharmacology of second generation atypical antipsychotic agents. Current investigations focus on the differences in interactions of typical and atypical antipsychotics with glutamatergic neurotransmission.
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Research Support
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GA Gudelsky (PI)
,NIDA,
Determinants and Consequences of MDMA-Induced 5-HT Neurotoxicity
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GA Gudelsky (Co-I)
,NIMH,
Antipsychotics, hypoglycemia, glutamate and cognition
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Publications
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Peer Reviewed Publications
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Darvesh, A, Yamamoto, BK and Gudelsky, GA. (2005). Evidence for the involvement of nitric oxide in 3,4-methyeledioxymethamphetamine-induced serotonin depletion in the rat brain. J. Pharmacol. Exp. Ther, 312, 694-701.
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Nair, SG and Gudelsky, GA (2005). 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex. Synapse, 58, 229-235.
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Straiko, MM, Gudelsky, GA and Coolen, LM (2007). Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats. Behavioral Neuroscience, 121(3), 58-593.
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Straiko, MM, Coolen, LM, Zemlan, FP and Gudelsky, GA (2007). The effect of amphetamine analogs on cleaved microtubule associated protein-tau formation in the rat brain. Neuroscience, 144, 223-231.
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Herring, HR, Scheaefer, TL, Tang, PH, Skelton, MR, Lucot, JP, Gudelsky, GA, Vorhees, CV, Williams, MT (2008). (In Press).Comparisoin of time-dependent effects of (+)-methamphetamine or forced swim on monoamine, glucose, and creatine in rats. BMC Neuroscience.
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Herring, NR, Schaefer, TL, Gudelsky, GA, Vorhees, CV, Williams, MT (2008). (In Press).Effect of (+)-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats. Psychopharmacology.
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Gudelsky, GA and Yamamoto, BK (2008). Actions of 3,4methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacology, Biochemistry and Behavior, 90, 198-207.
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Schaefer, TL, Skelton, MR, Herring, NR, Gudelsky, GA, Vorhees, CV, Williams, MT (2008). Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. J. Neurochemistry, 104, 1674-1685.
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Education
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Institution:Kalamazoo College
BA Chemistry
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Institution:Michigan State University
PhD in Pharmacology
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Keywords
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Dopamine,Clozapine,Serotonin,Haloperidol,Pentazocine,Pcp Receptor,Drug Receptor,Microdialysis,Schizophrenia,Laboratory Rat,Neurochemistry,Corpus Striatum,Methamphetamine,Neurotransmitter,Neuropharmacology,Antipsychotic Agent,Stereotaxic Technique
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MDMA
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Research and Practice Interests
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Neuropharmacology of amphetamines
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