Faculty & Staff

Gary Gudelsky, PhD

Professor

Education/Credentials
  • BA Chemistry: Kalamazoo College
  • PhD in Pharmacology: Michigan State University

Research/Clinical Interests

Neuropharmacology of amphetamines

Contact Information

Peer Reviewed Publications

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Collins, Stuart A; Huff, Courtney; Chiaia, Nicolas; Gudelsky, Gary A; Yamamoto, Bryan K 2016. 3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling. Journal of neurochemistry, 136 5, 1074-84

Huff, Courtney L; Morano, Rachel L; Herman, James P; Yamamoto, Bryan K; Gudelsky, Gary A 2016. MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate. Neurotoxicology, 57 , 282-290

Collins, Stuart A; Gudelsky, Gary A; Yamamoto, Bryan K 2015. MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors. European journal of pharmacology, 761 , 95-100

Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B 2015. Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas. Molecular cancer therapeutics, 14 4, 857-64

Krishan, Mansi; Gudelsky, Gary A; Desai, Pankaj B; Genter, Mary Beth 2014. Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain. Drug delivery, 21 1, 8-16

Weber, Georg F; Johnson, Bethann N; Yamamoto, Bryan K; Gudelsky, Gary A 2014. Effects of stress and MDMA on hippocampal gene expression. BioMed research international, 2014 , 141396

Anneken, John H; Cunningham, Jacobi I; Collins, Stuart A; Yamamoto, Bryan K; Gudelsky, Gary A 2013. MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8 1, 58-65

Dave, Nimita; Gudelsky, Gary A; Desai, Pankaj B 2013. The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis. Cancer chemotherapy and pharmacology, 72 2, 349-57

Huff, Courtney; Bhide, Nirmal; Schroering, Allen; Yamamoto, Bryan K; Gudelsky, Gary A 2013. Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake. Brain research bulletin, 91 , 52-7

Isom, Amanda M; Gudelsky, Gary A; Benoit, Stephen C; Richtand, Neil M 2013. Antipsychotic medications, glutamate, and cell death: A hidden, but common medication side effect? Medical hypotheses, 80 3, 252-8

Anneken, John H; Gudelsky, Gary A 2012. MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus. Neuropharmacology, 63 6, 1022-7

Roenker, Nicole L; Gudelsky, Gary A; Ahlbrand, Rebecca; Horn, Paul S; Richtand, Neil M 2012. Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex. Neuropharmacology, 63 4, 575-81

Schaefer, Tori L; Grace, Curtis E; Skelton, Matthew R; Graham, Devon L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2012. Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats. ACS chemical neuroscience, 3 1, 12-21

Darvesh, Altaf S; Carroll, Richard T; Geldenhuys, Werner J; Gudelsky, Gary A; Klein, Jochen; Meshul, Charles K; Van der Schyf, Cornelis J 2011. In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery. Expert opinion on drug discovery, 6 2, 109-127

Roenker, NL, Gudelsky, GA, Ahlbrand, R, Bronson, SL, Kern,JR, Waterman, H and Richtand, NM 2011. Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801 Neuroscience Letters, 500 , 575-581

Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2010. (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia. Synapse (New York, N.Y.), 64 10, 773-85

Pachmerhiwala, Rashida; Bhide, Nirmal; Straiko, Megan; Gudelsky, Gary A 2010. Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain. European journal of pharmacology, 644 1-3, 67-72

Schaefer, T L; Grace, C E; Gudelsky, G A; Vorhees, C V; Williams, M T 2010. Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats. Stress (Amsterdam, Netherlands), 13 6, 469-80

Yamamoto, Bryan K; Moszczynska, Anna; Gudelsky, Gary A 2010. Amphetamine toxicities: classical and emerging mechanisms. Annals of the New York Academy of Sciences, 1187 , 101-21

Bhide, Nirmal S; Lipton, Jack W; Cunningham, Jacobi I; Yamamoto, Bryan K; Gudelsky, Gary A 2009. Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain. Brain research, 1286 , 32-41

Apparaju, Sandhya Kiran; Gudelsky, Gary A; Desai, Pankaj B 2008. Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis. Cancer chemotherapy and pharmacology, 61 2, 223-9

Gudelsky, GA and Yamamoto, BK 2008. Actions of 3,4methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacology, Biochemistry and Behavior, 90 , 198-207

Gudelsky, Gary A; Yamamoto, Bryan K 2008. Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacology, biochemistry, and behavior, 90 2, 198-207

Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. Effect of +-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats. Psychopharmacology, 199 4, 637-50

Herring, Nicole R; Schaefer, Tori L; Tang, Peter H; Skelton, Matthew R; Lucot, James P; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC neuroscience, 9 2, 49-59

Schaefer, TL, Skelton, MR, Herring, NR, Gudelsky, GA, Vorhees, CV, Williams, MT 2008. Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. J. Neurochemistry, 104 , 1674-1685

Schaefer, Tori L; Skelton, Matthew R; Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. Journal of neurochemistry, 104 6, 1674-85

Skelton, Matthew R; Able, Jessica A; Grace, Curtis E; Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology, 55 7, 1121-30

Straiko, M M W; Coolen, L M; Zemlan, F P; Gudelsky, G A 2007. The effect of amphetamine analogs on cleaved microtubule-associated protein-tau formation in the rat brain. Neuroscience, 144 1, 223-31

Straiko, Megan M W; Gudelsky, Gary A; Coolen, Lique M 2007. Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats. Behavioral neuroscience, 121 3, 586-93

Straiko, MM, Coolen, LM, Zemlan, FP and Gudelsky, GA 2007. The effect of amphetamine analogs on cleaved microtubule associated protein-tau formation in the rat brain Neuroscience, 144 , 223-231

Straiko, MM, Gudelsky, GA and Coolen, LM 2007. Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats Behavioral Neuroscience, 121 3, 58-593

Able, Jessica A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biological psychiatry, 59 12, 1219-26

Nair, S G; Gudelsky, G A 2006. Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex. Brain research bulletin, 69 4, 382-7

Nair, Sunila G; Gudelsky, Gary A 2006. 3,4-Methylenedioxymethamphetamine enhances the release of acetylcholine in the prefrontal cortex and dorsal hippocampus of the rat. Psychopharmacology, 184 2, 182-9

Schaefer, Tori L; Ehrman, Lisa A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2006. Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. Journal of neurochemistry, 98 5, 1369-78

Darvesh, A, Yamamoto, BK and Gudelsky, GA. 2005. Evidence for the involvement of nitric oxide in 3,4-methyeledioxymethamphetamine-induced serotonin depletion in the rat brain J. Pharmacol. Exp. Ther, 312 , 694-701

Darvesh, Altaf S; Gudelsky, Gary A 2005. Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT Brain research, 1056 2, 168-75

Darvesh, Altaf S; Yamamoto, Bryan K; Gudelsky, Gary A 2005. Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain. The Journal of pharmacology and experimental therapeutics, 312 2, 694-701

Nair, SG and Gudelsky, GA 2005. 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex Synapse, 58 , 229-235

Nair, Sunila G; Gudelsky, Gary A 2005. 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex. Synapse (New York, N.Y.), 58 4, 229-35

Williams, Michael T; Schaefer, Tori L; Ehrman, Lisa A; Able, Jessica A; Gudelsky, Gary A; Sah, Renu; Vorhees, Charles V 2005. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. Brain research, 1039 1-2, 97-107

Nair, Sunila G; Gudelsky, Gary A 2004. Protein kinase C inhibition differentially affects 3,4-methylenedioxymethamphetamine-induced dopamine release in the striatum and prefrontal cortex of the rat. Brain research, 1013 2, 168-73

Nair, Sunila G; Gudelsky, Gary A 2004. Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat. Synapse (New York, N.Y.), 53 4, 202-7

Skelton, Matthew R; Blankenmeyer, Tracy L; Gudelsky, Gary A; Brown-Strittholt, Carrie A; Vorhees, Charles V; Williams, Michael T 2004. Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats. Synapse (New York, N.Y.), 54 4, 214-22

Darvesh, Altaf S; Gudelsky, Gary A 2003. Activation of 5-HT2 receptors induces glycogenolysis in the rat brain. European journal of pharmacology, 464 2-3, 135-40

Gudelsky, Gary A; Yamamoto, Bryan K 2003. Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine. Methods in molecular medicine, 79 , 55-73

Wallace, T L; Vorhees, C V; Zemlan, F P; Gudelsky, G A 2003. Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain. Neuroscience, 116 4, 1063-8

Williams, Michael T; Blankenmeyer, Tracy L; Schaefer, Tori L; Brown, Carrie A; Gudelsky, Gary A; Vorhees, Charles V 2003. Long-term effects of neonatal methamphetamine exposure in rats on spatial learning in the Barnes maze and on cliff avoidance, corticosterone release, and neurotoxicity in adulthood. Brain research. Developmental brain research, 147 1-2, 163-75

Darvesh, Altaf S; Shankaran, Mahalakshmi; Gudelsky, Gary A 2002. 3,4-Methylenedioxymethamphetamine produces glycogenolysis and increases the extracellular concentration of glucose in the rat brain. The Journal of pharmacology and experimental therapeutics, 301 1, 138-44

Shankaran, M; Yamamoto, B K; Gudelsky, G A 2001. Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT. Synapse (New York, N.Y.), 40 1, 55-64

Wallace, T L; Gudelsky, G A; Vorhees, C V 2001. Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine. Psychopharmacology, 153 3, 321-6

Wallace, T L; Gudelsky, G A; Vorhees, C V 2001. Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat. Synapse (New York, N.Y.), 39 1, 1-7

Wallace, T L; Vorhees, C V; Gudelsky, G A 2001. Effects of lubeluzole on the methamphetamine-induced increase in extracellular glutamate and the long-term depletion of striatal dopamine. Synapse (New York, N.Y.), 40 2, 95-101

Shankaran, M; Gudelsky, G A 1999. A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration. Psychopharmacology, 147 1, 66-72

Shankaran, M; Yamamoto, B K; Gudelsky, G A 1999. Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. European journal of pharmacology, 385 2-3, 103-10

Shankaran, M; Yamamoto, B K; Gudelsky, G A 1999. Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum. Journal of neurochemistry, 72 6, 2516-22

Wallace, T L; Gudelsky, G A; Vorhees, C V 1999. Methamphetamine-induced neurotoxicity alters locomotor activity, stereotypic behavior, and stimulated dopamine release in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19 20, 9141-8

Shankaran, M; Gudelsky, G A 1998. Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin. Pharmacology, biochemistry, and behavior, 61 4, 361-6

Gudelsky, G A 1996. Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin. Journal of neural transmission (Vienna, Austria : 1996), 103 12, 1397-404

Gudelsky, G A; Nash, J F 1996. Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. Journal of neurochemistry, 66 1, 243-9

Gudelsky, G A; Nwajei, E E; Defife, K; Nash, J F 1992. Effects of amfonelic acid and GBR 12909 on the haloperidol- and clozapine-induced activation of dopamine neurons. Psychopharmacology bulletin, 28 3, 275-9

Nash, J F; Meltzer, H Y; Gudelsky, G A 1988. Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. European journal of pharmacology, 151 3, 463-9

Darvesh, Altaf S; Gudelsky, Gary A . The relationship between hyperthermia and glycogenolysis in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats. Neurotoxicology and teratology, 26 4, 571-7

Grace, Curtis E; Schaefer, Tori L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V . Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and teratology, 32 3, 356-61

Grace, Curtis E; Schaefer, Tori L; Herring, Nicole R; Graham, Devon L; Skelton, Matthew R; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V . Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice. Neurotoxicology and teratology, 32 3, 346-55

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