Faculty & Staff

Gerald Kasting

Education/Credentials
  • Ph.D.: Massachusetts Institute of Technology
  • B.A.: Vanderbilt University

Contact Information

Peer Reviewed Publications

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Dancik, Yuri; Miller, Matthew A; Jaworska, Joanna; Kasting, Gerald B 2013. Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure. Advanced drug delivery reviews, 65 2, 221-36

Nitsche, Johannes M; Kasting, Gerald B 2013. A correlation for 1,9-decadiene/water partition coefficients. Journal of pharmaceutical sciences, 102 1, 136-44

Ibrahim, Rania; Kasting, Gerald B 2012. Partitioning and diffusion of parathion in human dermis. International journal of pharmaceutics, 435 1, 33-7

Ibrahim, Rania; Nitsche, Johannes M; Kasting, Gerald B 2012. Dermal clearance model for epidermal bioavailability calculations. Journal of pharmaceutical sciences, 101 6, 2094-108

Karr, Jennifer I; Speaker, Tycho J; Kasting, Gerald B 2012. A novel encapsulation of N,N-diethyl-3-methylbenzamide (DEET) favorably modifies skin absorption while maintaining effective evaporation rates. Journal of controlled release : official journal of the Controlled Release Society, 160 3, 502-8

Hansen, Steffi; Selzer, Dominik; Schaefer, Ulrich F; Kasting, Gerald B 2011. An extended database of keratin binding. Journal of pharmaceutical sciences, 100 5, 1712-26

Mitragotri, Samir; Anissimov, Yuri G; Bunge, Annette L; Frasch, H Frederick; Guy, Richard H; Hadgraft, Jonathan; Kasting, Gerald B; Lane, Majella E; Roberts, Michael S 2011. Mathematical models of skin permeability: an overview. International journal of pharmaceutics, 418 1, 115-29

Ibrahim, Rania; Kasting, Gerald B 2010. Improved method for determining partition and diffusion coefficients in human dermis. Journal of pharmaceutical sciences, 99 12, 4928-39

Miller, Matthew A; Kasting, Gerald B 2010. Toward a better understanding of pesticide dermal absorption: diffusion model analysis of parathion absorption in vitro and in vivo. Journal of toxicology and environmental health. Part A, 73 4, 284-300

Fischer, L A; Menné, T; Avnstorp, C; Kasting, G B; Johansen, J D 2009. Hydroxyisohexyl 3-cyclohexene carboxaldehyde allergy: relationship between patch test and repeated open application test thresholds. The British journal of dermatology, 161 3, 560-7

Yadav, Santosh; Wickett, R Randall; Pinto, Neville G; Kasting, Gerald B; Thiel, Stephen W 2009. Comparative thermodynamic and spectroscopic properties of water interaction with human stratum corneum. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 15 2, 172-9

Barai, Namrata D; Boyce, Steven T; Hoath, Steven B; Visscher, Marty O; Kasting, Gerald B 2008. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 14 4, 418-24

Bhatt, Varsha D; Soman, Rajiv S; Miller, Matthew A; Kasting, Gerald B 2008. Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS. Environmental science & technology, 42 17, 6587-92

Kasting, Gerald B; Bhatt, Varsha D; Speaker, Tycho J 2008. Microencapsulation decreases the skin absorption of N,N-diethyl-m-toluamide (DEET). Toxicology in vitro : an international journal published in association with BIBRA, 22 2, 548-52

Kasting, Gerald B; Miller, Matthew A; Bhatt, Varsha D 2008. A spreadsheet-based method for estimating the skin disposition of volatile compounds: application to N,N-diethyl-m-toluamide (DEET). Journal of occupational and environmental hygiene, 5 10, 633-44

Kretsos, Kosmas; Miller, Matthew A; Zamora-Estrada, Grettel; Kasting, Gerald B 2008. Partitioning, diffusivity and clearance of skin permeants in mammalian dermis. International journal of pharmaceutics, 346 1-2, 64-79

Barai, Namrata D; Supp, Andrew P; Kasting, Gerald B; Visscher, Marty O; Boyce, Steven T 2007. Improvement of epidermal barrier properties in cultured skin substitutes after grafting onto athymic mice. Skin pharmacology and physiology, 20 1, 21-8

Gunt, Hemali B; Kasting, Gerald B 2007. Effect of hydration on the permeation of ketoconazole through human nail plate in vitro. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 32 4-5, 254-60

Gunt, Hemali B; Miller, Matthew A; Kasting, Gerald B 2007. Water diffusivity in human nail plate. Journal of pharmaceutical sciences, 96 12, 3352-62

Kretsos, Kosmas; Kasting, Gerald B 2007. A geometrical model of dermal capillary clearance. Mathematical biosciences, 208 2, 430-53

Wang, Tsuo-Feng; Kasting, Gerald B; Nitsche, Johannes M 2007. A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. Journal of pharmaceutical sciences, 96 11, 3024-51

Yadav, Santosh; Pinto, Neville G; Kasting, Gerald B 2007. Thermodynamics of water interaction with human stratum corneum I: measurement by isothermal calorimetry. Journal of pharmaceutical sciences, 96 6, 1585-97

Kasting, Gerald B; Miller, Matthew A 2006. Kinetics of finite dose absorption through skin 2: volatile compounds. Journal of pharmaceutical sciences, 95 2, 268-80

Khalil, Enam; Kretsos, Kosmas; Kasting, Gerald B 2006. Glucose partition coefficient and diffusivity in the lower skin layers. Pharmaceutical research, 23 6, 1227-34

Miller, Matthew A; Bhatt, Varsha; Kasting, Gerald B 2006. Dose and airflow dependence of benzyl alcohol disposition on skin. Journal of pharmaceutical sciences, 95 2, 281-91

Nitsche, Johannes M; Wang, Tsuo-Feng; Kasting, Gerald B 2006. A two-phase analysis of solute partitioning into the stratum corneum. Journal of pharmaceutical sciences, 95 3, 649-66

Wang, Tsuo-Feng; Kasting, Gerald B; Nitsche, Johannes M 2006. A multiphase microscopic diffusion model for stratum corneum permeability. I. Formulation, solution, and illustrative results for representative compounds. Journal of pharmaceutical sciences, 95 3, 620-48

Chilcott, R P; Barai, N; Beezer, A E; Brain, S I; Brown, M B; Bunge, A L; Burgess, S E; Cross, S; Dalton, C H; Dias, M; Farinha, A; Finnin, B C; Gallagher, S J; Green, D M; Gunt, H; Gwyther, R L; Heard, C M; Jarvis, C A; Kamiyama, F; Kasting, G B; Ley, E E; Lim, S T; McNaughton, G S; Morris, A; Nazemi, M H; Pellett, M A; Du Plessis, J; Quan, Y S; Raghavan, S L; Roberts, M; Romonchuk, W; Roper, C S; Schenk, D; Simonsen, L; Simpson, A; Traversa, B D; Trottet, L; Watkinson, A; Wilkinson, S C; Williams, F M; Yamamoto, A; Hadgraft, J 2005. Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials. Journal of pharmaceutical sciences, 94 3, 632-8

Santhanam, Arjun; Miller, Matthew A; Kasting, Gerald B 2005. Absorption and evaporation of N,N-diethyl-m-toluamide from human skin in vitro. Toxicology and applied pharmacology, 204 1, 81-90

Kretsos, Kosmas; Kasting, Gerald B; Nitsche, Johannes M 2004. Distributed diffusion-clearance model for transient drug distribution within the skin. Journal of pharmaceutical sciences, 93 11, 2820-35

Saiyasombati, Penpan; Kasting, Gerald B 2004. In vivo evaporation rate of benzyl alcohol from human skin. Journal of pharmaceutical sciences, 93 2, 515-20

Kasting, Gerald B; Barai, Namrata D 2003. Equilibrium water sorption in human stratum corneum. Journal of pharmaceutical sciences, 92 8, 1624-31

Kasting, Gerald B; Barai, Namrata D; Wang, Tsuo-Feng; Nitsche, Johannes M 2003. Mobility of water in human stratum corneum. Journal of pharmaceutical sciences, 92 11, 2326-40

Saiyasombati, P; Kasting, G B 2003. Two-stage kinetic analysis of fragrance evaporation and absorption from skin. International journal of cosmetic science, 25 5, 235-43

Saiyasombati, Penpan; Kasting, Gerald B 2003. Disposition of benzyl alcohol after topical application to human skin in vitro. Journal of pharmaceutical sciences, 92 10, 2128-39

Kasting, G B 2001. Kinetics of finite dose absorption through skin 1. Vanillylnonanamide. Journal of pharmaceutical sciences, 90 2, 202-12

Kasting, G B; Saiyasombati, P 2001. A physico-chemical properties based model for estimating evaporation and absorption rates of perfumes from skin. International journal of cosmetic science, 23 1, 49-58

Talreja, P; Kleene, N K; Pickens, W L; Wang, T F; Kasting, G B 2001. Visualization of the lipid barrier and measurement of lipid pathlength in human stratum corneum. AAPS pharmSci, 3 2, E13

Kasting, G B; Francis, W R; Bowman, L A; Kinnett, G O 1997. Percutaneous absorption of vanilloids: in vivo and in vitro studies. Journal of pharmaceutical sciences, 86 1, 142-6

Kasting, G B; Filloon, T G; Francis, W R; Meredith, M P 1994. Improving the sensitivity of in vitro skin penetration experiments. Pharmaceutical research, 11 12, 1747-54

Janusz, J M; Buckwalter, B L; Young, P A; LaHann, T R; Farmer, R W; Kasting, G B; Loomans, M E; Kerckaert, G A; Maddin, C S; Berman, E F 1993. Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. Journal of medicinal chemistry, 36 18, 2595-604

Kasting, G B; Francis, W R; Roberts, G E 1993. Skin penetration enhancement of triprolidine base by propylene glycol. Journal of pharmaceutical sciences, 82 5, 551-2

Kasting, G B; Robinson, P J 1993. Can we assign an upper limit to skin permeability? Pharmaceutical research, 10 6, 930-1

Kasting, G B; Francis, M D 1992. Retention of etidronate in human, dog, and rat. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 7 5, 513-22

Kasting, G B; Bowman, L A 1990. Electrical analysis of fresh, excised human skin: a comparison with frozen skin. Pharmaceutical research, 7 11, 1141-6

Kasting, G B; Bowman, L A 1990. DC electrical properties of frozen, excised human skin. Pharmaceutical research, 7 2, 134-43

Wehmeyer, K R; Kasting, G B; Powell, J H; Kuhlenbeck, D L; Underwood, R A; Bowman, L A 1990. Application of liquid chromatography with on-line radiochemical detection to metabolism studies on a novel class of analgesics. Journal of pharmaceutical and biomedical analysis, 8 2, 177-83

Taulbee, J D; Kasting, G B 1988. A nonparametric method for evaluating results from laboratory antinociceptive tests. Journal of pharmacological methods, 20 3, 197-206

Gunt, Hemal B; Kasting, Gerald B . Equilibrium water sorption characteristics of the human nail. Journal of cosmetic science, 58 1, 1-9

Gunt, Hemali; Kasting, Gerald B . Hydration effect on human nail permeability. Journal of cosmetic science, 57 2, 183-4

Kretsos, K; Kasting, G B . Dermal capillary clearance: physiology and modeling. Skin pharmacology and physiology, 18 2, 55-74

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