Faculty & Staff

Kevin Li, PhD

Professor

Education/Credentials
  • B.A.: Brigham Young University.
  • Ph.D.: University of Utah.

Contact Information

Peer Reviewed Publications

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Updated List of All Publications 2017. Click link , ,

Chantasart, Doungdaw; Hao, Jinsong; Li, S Kevin 2013. Evaluation of skin permeation of beta-blockers for topical drug delivery. Pharmaceutical research, 30 3, 866-77

Chopra, Poonam; Hao, Jinsong; Li, S Kevin 2013. Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera. Journal of pharmaceutical sciences, 102 2, 480-8

Li, S K; Peck, K D 2013. Passive and iontophoretic transport through the skin polar pathway. Skin pharmacology and physiology, 26 4-6, 243-53

Liu, Hongzhuo; Feng, Liang; Tolia, Gaurav; Liddell, Mark R; Hao, Jinsong; Li, S Kevin 2013. Evaluation of intratympanic formulations for inner ear delivery: methodology and sustained release formulation testing. Drug development and industrial pharmacy, ,

Tolia, Gaurav; Li, S Kevin 2013. Silicone Adhesive Matrix of Verapamil Hydrochloride to Provide pH-Independent Sustained Release. AAPS PharmSciTech, ,

Wen, He; Hao, Jinsong; Li, S Kevin 2013. Characterization of human sclera barrier properties for transscleral delivery of bevacizumab and ranibizumab. Journal of pharmaceutical sciences, 102 3, 892-903

Chopra, Poonam; Hao, Jinsong; Li, S Kevin 2012. Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera. Journal of controlled release : official journal of the Controlled Release Society, 160 1, 96-104

Li, S Kevin; Hao, Jinsong; Liu, Hongshan; Lee, Jing-huei 2012. MRI study of subconjunctival and intravitreal injections. Journal of pharmaceutical sciences, 101 7, 2353-63

Tolia, Gaurav; Li, S Kevin 2012. Study of drug release and tablet characteristics of silicone adhesive matrix tablets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 82 3, 518-25

Hao, Jinsong; Yang, Michael B; Liu, Hongzhuo; Li, S Kevin 2011. Distribution of propranolol in periocular tissues: a comparison of topical and systemic administration. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 27 5, 453-9

Li, S Kevin; Liddell, Mark R; Wen, He 2011. Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis. Journal of pharmaceutical and biomedical analysis, 55 3, 603-7

Liddell, Mark R; Li, S Kevin; Higuchi, William I 2011. Transport behavior of hairless mouse skin during constant current DC iontophoresis, part 2: iontophoresis of nonionic molecules with cotransport of polystyrene sulfonate oligomers. Journal of pharmaceutical sciences, 100 7, 2816-25

Liddell, Mark R; Li, S Kevin; Higuchi, William I 2011. Transport behavior of hairless mouse skin during constant current DC iontophoresis i: Baseline studies. Journal of pharmaceutical sciences, 100 4, 1475-87

Shi, Xianfeng; Liu, Xin; Wu, Xueming; Lu, Zheng-Rong; Li, S Kevin; Jeong, Eun-Kee 2011. Ocular pharmacokinetic study using T1 mapping and Gd-chelate- labeled polymers. Pharmaceutical research, 28 12, 3180-8

Smith, Kelly A; Hao, Jinsong; Li, S Kevin 2011. Effects of organic solvents on the barrier properties of human nail. Journal of pharmaceutical sciences, ,

Chantasart, D.; Li, S. K. 2010. Relationship between the enhancement effects of chemical permeation enhancers on the lipoidal transport pathway across human skin under the symmetric and asymmetric conditions in vitro Pharm Res, 27 9 , 1825-36

Chopra, P.; Hao, J.; Li, S. K. 2010. Iontophoretic transport of charged macromolecules across human sclera Int J Pharm, 388 1-2 , 107-13

D. Khondkar; P. Chopra; J.P. McArter; J.A. Rosen; S.K. Li 2010. Chemical stability of hydromorphone hydrochloride in patient-controlled analgesia injector. Int J Pharm Compound, 14 2 , 160-164

Hao, J.; Li, S. K.; Kao, W. W.; Liu, C. Y. 2010. Gene delivery to cornea Brain Res Bull, 81 2-3 , 256-61

Hao, J.; Smith, K. A.; Li, S. K. 2010. Time-dependent electrical properties of human nail upon hydration in vivo J Pharm Sci, 99 1 , 107-18

Ibrahim, S. A.; Li, S. K. 2010. Efficiency of fatty acids as chemical penetration enhancers: mechanisms and structure enhancement relationship Pharm Res, 27 1 , 115-25

Ibrahim, S. A.; Li, S. K. 2010. Chemical enhancer solubility in human stratum corneum lipids and enhancer mechanism of action on stratum corneum lipid domain Int J Pharm, 383 1-2 , 89-98

Liu, X.; Li, S. K.; Jeong, E. K. 2010. Ocular pharmacokinetic study of a corticosteroid by 19F MR Exp Eye Res, 91 3 , 347-52

Smith, K. A.; Hao, J.; Li, S. K. 2010. Influence of pH on transungual passive and iontophoretic transport J Pharm Sci, 99 4 , 1955-67

Wen, H.; Hao, J.; Li, S. K. 2010. Influence of permeant lipophilicity on permeation across human sclera Pharm Res, 27 11 , 2446-56

Chantasart, D.; Pongjanyakul, T.; Higuchi, W. I.; Li, S. K. 2009. Effects of oxygen-containing terpenes as skin permeation enhancers on the lipoidal pathways of human epidermal membrane J Pharm Sci, 98 10 , 3617-32

Hao, J.; Li, S. K.; Liu, C. Y.; Kao, W. W. 2009. Electrically assisted delivery of macromolecules into the corneal epithelium Exp Eye Res, 89 6 , 934-41

Hao, J.; Smith, K. A.; Li, S. K. 2009. Iontophoretically enhanced ciclopirox delivery into and across human nail plate J Pharm Sci, 98 10 , 3608-16

Ibrahim, S. A.; Li, S. K. 2009. Effects of solvent deposited enhancers on transdermal permeation and their relationship with Emax J Control Release, 136 2 , 117-24

Ibrahim, S. A.; Li, S. K. 2009. Effects of chemical enhancers on human epidermal membrane: Structure-enhancement relationship based on maximum enhancement (E(max)) J Pharm Sci, 98 3 , 926-44

Molokhia, S. A.; Jeong, E. K.; Higuchi, W. I.; Li, S. K. 2009. Transscleral iontophoretic and intravitreal delivery of a macromolecule: study of ocular distribution in vivo and postmortem with MRI Exp Eye Res, 88 3 , 418-25

Smith, K. A.; Hao, J.; Li, S. K. 2009. Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail Pharm Res, 26 6 , 1446-55

Xu, Q.; Ibrahim, S. A.; Higuchi, W. I.; Li, S. K. 2009. Ion-exchange membrane assisted transdermal iontophoretic delivery of salicylate and acyclovir Int J Pharm, 369 1-2 , 105-13

Xu, Q.; Kochambilli, R. P.; Song, Y.; Hao, J.; Higuchi, W. I.; Li, S. K. 2009. Effects of alternating current frequency and permeation enhancers upon human epidermal membrane Int J Pharm, 372 1-2 , 24-32

Hao, J.; Li, S. K. 2008. Mechanistic study of electroosmotic transport across hydrated nail plates: effects of pH and ionic strength J Pharm Sci, 97 12 , 5186-97

Hao, J.; Li, S. K. 2008. Transungual iontophoretic transport of polar neutral and positively charged model permeants: effects of electrophoresis and electroosmosis J Pharm Sci, 97 2 , 893-905

Hao, J.; Smith, K. A.; Li, S. K. 2008. Chemical method to enhance transungual transport and iontophoresis efficiency Int J Pharm, 357 1-2 , 61-9

Hao, Jinsong; Li, S Kevin 2008. Mechanistic study of electroosmotic transport across hydrated nail plates: effects of pH and ionic strength. Journal of pharmaceutical sciences, 97 12, 5186-97

Li, S. K.; Lizak, M. J.; Jeong, E. K. 2008. MRI in ocular drug delivery NMR Biomed, 21 9 , 941-56

Miller, D. J.; Li, S. K.; Tuitupou, A. L.; Kochambilli, R. P.; Papangkorn, K.; Mix, D. C., Jr.; Higuchi, W. I.; Higuchi, J. W. 2008. Passive and oxymetazoline-enhanced delivery with a lens device: pharmacokinetics and efficacy studies with rabbits J Ocul Pharmacol Ther, 24 4 , 385-91

Molokhia, S. A.; Jeong, E. K.; Higuchi, W. I.; Li, S. K. 2008. Examination of barriers and barrier alteration in transscleral iontophoresis J Pharm Sci, 97 2 , 831-44

Molokhia, S. A.; Zhang, Y.; Higuchi, W. I.; Li, S. K. 2008. Iontophoretic transport across a multiple membrane system J Pharm Sci, 97 1 , 490-505

Suhonen, M.; Li, S. K.; Higuchi, W. I.; Herron, J. N. 2008. A liposome permeability model for stratum corneum lipid bilayers based on commercial lipids J Pharm Sci, 97 10 , 4278-93

Tsutsumi, K.; Li, S. K.; Hymas, R. V.; Teng, C. L.; Tillman, L. G.; Hardee, G. E.; Higuchi, W. I.; Ho, N. F. 2008. Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer J Pharm Sci, 97 1 , 350-67

Warner, K. S.; Shaker, D. S.; Molokhia, S.; Xu, Q.; Hao, J.; Higuchi, W. I.; Li, S. K. 2008. Silicone elastomer uptake method for determination of free 1-alkyl-2-pyrrolidone concentration in micelle and hydroxypropyl-beta-cyclodextrin systems used in skin transport studies J Pharm Sci, 97 1 , 368-80

Yan, G.; Xu, Q.; Anissimov, Y. G.; Hao, J.; Higuchi, W. I.; Li, S. K. 2008. Alternating current (AC) iontophoretic transport across human epidermal membrane: effects of AC frequency and amplitude Pharm Res, 25 3 , 616-24

Chantasart, D.; Sa-Nguandeekul, P.; Prakongpan, S.; Li, S. K.; Higuchi, W. I. 2007. Comparison of the effects of chemical permeation enhancers on the lipoidal pathways of human epidermal membrane and hairless mouse skin and the mechanism of enhancer action J Pharm Sci, 96 9 , 2310-26

Longo, N.; Li, S. K.; Yan, G.; Kochambilli, R. P.; Papangkorn, K.; Berglund, D.; Ghanem, A. H.; Ashurst, C. L.; Ernst, S. L.; Pasquali, M.; Higuchi, W. I. 2007. Noninvasive measurement of phenylalanine by iontophoretic extraction in patients with phenylketonuria J Inherit Metab Dis, 30 6 , 910-5

Molokhia, S. A.; Jeong, E. K.; Higuchi, W. I.; Li, S. K. 2007. Examination of penetration routes and distribution of ionic permeants during and after transscleral iontophoresis with magnetic resonance imaging Int J Pharm, 335 1-2 , 46-53

Li, S. K.; Zhu, H.; Higuchi, W. I. 2006. Enhanced transscleral lontophoretic transport with ion-exchange membrane Pharm Res, 23 8 , 1857-67

He, N.; Warner, K. S.; Higuchi, W. I.; Li, S. K. 2005. Model analysis of flux enhancement across hairless mouse skin induced by chemical permeation enhancers Int J Pharm, 297 1-2 , 9-21

Li, S. K.; Zhang, Y.; Zhu, H.; Higuchi, W. I.; White, H. S. 2005. Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport J Pharm Sci, 94 4 , 847-60

Yan, G.; Li, S. K.; Higuchi, W. I. 2005. Evaluation of constant current alternating current iontophoresis for transdermal drug delivery J Control Release, 110 1 , 141-50

Yan, G.; Peck, K. D.; Zhu, H.; Higuchi, W. I.; Li, S. K. 2005. Effects of electrophoresis and electroosmosis during alternating current iontophoresis across human epidermal membrane J Pharm Sci, 94 3 , 547-58

Chantasart, D.; Li, S. K.; He, N.; Warner, K. S.; Prakongpan, S.; Higuchi, W. I. 2004. Mechanistic studies of branched-chain alkanols as skin permeation enhancers J Pharm Sci, 93 3 , 762-79

He, N.; Warner, K. S.; Chantasart, D.; Shaker, D. S.; Higuchi, W. I.; Li, S. K. 2004. Mechanistic study of chemical skin permeation enhancers with different polar and lipophilic functional groups J Pharm Sci, 93 6 , 1415-30

Li, S. K.; Higuchi, W. I.; Kochambilli, R. P.; Zhu, H. 2004. Mechanistic studies of flux variability of neutral and ionic permeants during constant current dc iontophoresis with human epidermal membrane Int J Pharm, 273 1-2 , 9-22

Li, S. K.; Jeong, E. K.; Hastings, M. S. 2004. Magnetic resonance imaging study of current and ion delivery into the eye during transscleral and transcorneal iontophoresis Invest Ophthalmol Vis Sci, 45 4 , 1224-31

Li, S. K.; Molokhia, S. A.; Jeong, E. K. 2004. Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging Pharm Res, 21 12 , 2175-84

M.S. Hastings, S.K. Li, D.J. Miller, P.S. Bernstein, D. Mufson. 2004. Drug Delivery Technology, 4 3, 2-6

Yan, G.; Higuchi, W. I.; Szabo, A.; Li, S. K. 2004. Correlation of transdermal iontophoretic phenylalanine and mannitol transport: test of the internal standard concept under DC iontophoresis and constant resistance AC iontophoresis conditions J Control Release, 98 1 , 127-38

Yan, G.; Li, S. K.; Peck, K. D.; Zhu, H.; Higuchi, W. I. 2004. Quantitative study of electrophoretic and electroosmotic enhancement during alternating current iontophoresis across synthetic membranes J Pharm Sci, 93 12 , 2895-908

He, N.; Li, S. K.; Suhonen, T. M.; Warner, K. S.; Higuchi, W. I. 2003. Mechanistic study of alkyl azacycloheptanones as skin permeation enhancers by permeation and partition experiments with hairless mouse skin J Pharm Sci, 92 2 , 297-310

Li, S. K.; Higuchi, W. I.; Zhu, H.; Kern, S. E.; Miller, D. J.; Hastings, M. S. 2003. In vitro and in vivo comparisons of constant resistance AC iontophoresis and DC iontophoresis J Control Release, 91 3 , 327-43

Shaker, D. S.; Ghanem, A. H.; Li, S. K.; Warner, K. S.; Hashem, F. M.; Higuchi, W. I. 2003. Mechanistic studies of the effect of hydroxypropyl-beta-cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin Int J Pharm, 253 1-2 , 1-11

Tsutsumi, K.; Li, S. K.; Ghanem, A. H.; Ho, N. F.; Higuchi, W. I. 2003. A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes J Pharm Sci, 92 2 , 344-59

Warner, K. S.; Li, S. K.; He, N.; Suhonen, T. M.; Chantasart, D.; Bolikal, D.; Higuchi, W. I. 2003. Structure-activity relationship for chemical skin permeation enhancers: probing the chemical microenvironment of the site of action J Pharm Sci, 92 6 , 1305-22

Zhu, H.; Peck, K. D.; Miller, D. J.; Liddell, M. R.; Yan, G.; Higuchi, W. I.; Li, S. K. 2003. Investigation of properties of human epidermal membrane under constant conductance alternating current iontophoresis J Control Release, 89 1 , 31-46

Song, Y.; Li, S. K.; Peck, K. D.; Zhu, H.; Ghanem, A. H.; Higuchi, W. I. 2002. Human epidermal membrane constant conductance iontophoresis: alternating current to obtain reproducible enhanced permeation and reduced lag times of a nonionic polar permeant Int J Pharm, 232 1-2 , 45-57

Zhu, H.; Li, S. K.; Peck, K. D.; Miller, D. J.; Higuchi, W. I. 2002. Improvement on conventional constant current DC iontophoresis: a study using constant conductance AC iontophoresis J Control Release, 82 2-3 , 249-61

Li, S. K.; Ghanem, A. H.; Teng, C. L.; Hardee, G. E.; Higuchi, W. I. 2001. Iontophoretic transport of oligonucleotides across human epidermal membrane: a study of the Nernst-Planck model J Pharm Sci, 90 7 , 915-31

Warner, K. S.; Li, S. K.; Higuchi, W. I. 2001. Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement J Pharm Sci, 90 8 , 1143-53

Zhu, H.; Peck, K. D.; Li, S. K.; Ghanem, A. H.; Higuchi, W. I. 2001. Quantification of pore induction in human epidermal membrane during iontophoresis: the importance of background electrolyte selection J Pharm Sci, 90 7 , 932-42

Higuchi, W. I.; Li, S. K.; Ghanem, A. H.; Zhu, H.; Song, Y. 1999. Mechanistic aspects of iontophoresis in human epidermal membrane J Control Release, 62 1-2 , 13-23

Li, S. K.; Ghanem, A. H.; Higuchi, W. I. 1999. Pore charge distribution considerations in human epidermal membrane electroosmosis J Pharm Sci, 88 10 , 1044-9

Li, S. K.; Ghanem, A. H.; Peck, K. D.; Higuchi, W. I. 1999. Pore induction in human epidermal membrane during low to moderate voltage iontophoresis: A study using AC iontophoresis J Pharm Sci, 88 4 , 419-27

Li, S. K.; Ghanem, A. H.; Peck, K. D.; Higuchi, W. I. 1998. Characterization of the transport pathways induced during low to moderate voltage iontophoresis in human epidermal membrane J Pharm Sci, 87 1 , 40-8

Peck, K. D.; Hsu, J.; Li, S. K.; Ghanem, A. H.; Higuchi, W. I. 1998. Flux enhancement effects of ionic surfactants upon passive and electroosmotic transdermal transport J Pharm Sci, 87 9 , 1161-9

S.K. Li; W. Suh; H.H. Parikh; A-H. Ghanem; S.C. Mehta; K.D. Peck; W.I. Higuchi 1998. Lag time data for characterizing the pore pathway of intact and chemically pretreated human epidermal membrane Int. J. Pharm, 170 1 , 93-108

Yoneto, K.; Li, S. K.; Higuchi, W. I.; Shimabayashi, S. 1998. Influence of the permeation enhancers 1-alkyl-2-pyrrolidones on permeant partitioning into the stratum corneum J Pharm Sci, 87 2 , 209-14

Li, S. K.; Ghanem, A. H.; Peck, K. D.; Higuchi, W. I. 1997. Iontophoretic transport across a synthetic membrane and human epidermal membrane: a study of the effects of permeant charge J Pharm Sci, 86 6 , 680-9

Peck, K. D.; Srinivasan, V.; Li, S. K.; Higuchi, W. I.; Ghanem, A. H. 1996. Quantitative description of the effect of molecular size upon electroosmotic flux enhancement during iontophoresis for a synthetic membrane and human epidermal membrane J Pharm Sci, 85 7 , 781-8

Yoneto, K.; Li, S. K.; Higuchi, W. I.; Jiskoot, W.; Herron, J. N. 1996. Fluorescent probe studies of the interactions of 1-alkyl-2-pyrrolidones with stratum corneum lipid liposomes J Pharm Sci, 85 5 , 511-7

Yoneto, K.; Ghanem, A. H.; Higuchi, W. I.; Peck, K. D.; Li, S. K. 1995. Mechanistic studies of the 1-alkyl-2-pyrrolidones as skin permeation enhancers J Pharm Sci, 84 3 , 312-7

Yoneto, K.; Li, S. K.; Ghanem, A. H.; Crommelin, D. J.; Higuchi, W. I. 1995. A mechanistic study of the effects of the 1-alkyl-2-pyrrolidones on bilayer permeability of stratum corneum lipid liposomes: a comparison with hairless mouse skin studies J Pharm Sci, 84 7 , 853-61

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