Faculty & Staff

Giovanni Pauletti

Education/Credentials
  • MPharm - Pharmacy (1987): Swiss Federal Institute of Technology
  • PhD - Biopharmaceutics/Pharmacokinetics (1994): Swiss Federal Institute of Technology

Contact Information

Peer Reviewed Publications

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Abd Ellah, N., Taylor, L., Ayres, N., Elmahdy, M.M., Fetih, G.N., Ibrahim, E.A., and Pauletti, G.M. 2016. NF-κB Decoy Polyplexes Decrease P-glycoprotein-mediated Multidrug Resistance in Colorectal Cancer Cells. Cancer Gene Ther., 23 5, 149-155

Dunn, A.W., Zhang, Y., Mast, D.B., Pauletti, G.M., Xu, H., Zhang, J., Ewing, R.C., and Shi, D. 2016. In-vitro Depth-dependent Hyperthermia of Human Mammary Gland Adenocarcinoma. Mater. Sci. Eng. C, 69 , 12-16

Gad, S.F., Fetih, G.N., Tous, S.S., and Pauletti, G.M. 2016. Fabrication of Lipid-coated Chitosan Nanoparticles. Br. J. Pharm. Res., 13 , 1-8

Tucker, G., DeSilva, B., Dressman, J., Ito, M., Kumamoto, T., Mager, D., Mahler, H.C., Maitland-van der Zee, A.H., Pauletti, G.M., Sasaki, H., Shah, V., Tang, D., and Ward, M. 2016. Current Challenges and Potential Opportunities for the Pharmaceutical Sciences to Make Global Impact: An FIP Perspective. J. Pharm. Sci., 105 9, 344-351

Abd El Hamid, B., Soliman, G.M., Attia, M.A., and Pauletti, G.M. 2015. An Ion Pairing Approach to Enhance Oral Bioavailability of Alendronate. J. Sci. Res. Reports, 5 , 344-351

Abd Ellah, N., Taylor, L., Ayres, N., Pauletti, G.M., and Jones, H.N. 2015. Development of Non-viral, Trophoblast-specific Gene Delivery for Placental Therapy. PLoS One, 10 , e0140879

Dunn, A.W., Sadat, M.E., Mast, D.B., Pauletti, G.M., Xu, H., Zhang, J., Ewing, R.C., and Shi, D. 2015. Photothermal Effects and Toxicity of Fe3O4 Nanoparticles via Near Infrared Laser Irradiation for Cancer Therapy. Mater. Sci. Eng. C, 46 , 97-102

Eraky, N., Mohamed, D.F., Attia, M.A., and Pauletti, G.M. 2015. Hydrophobic Ion-Pairing of Low Molecular Weight Heparin with Cetyltrimethylammonium Bromide. Int. J. Pharma Sci. Res., 6 , 558-565

Abd Ellah, N., Potter, S.J., Taylor, L., Ayres, N., Elmahdy, M.M., Fetih, G.N., Ibrahim, E.A., and Pauletti, G.M. 2014. Safety and Efficacy of Amine-containing Methacrylate Polymers as Non-viral Gene Delivery Vectors. J. Pharm. Tech. Drug Res., 3 , 2

Abd Ellah, Taylor, L., Ayres, N., Elmahdy, M.M., Fetih, G.N., Ibrahim, E.A., and Pauletti, G.M. 2014. Increased Transfection Efficiency of Lipid-Coated Methacrylate-Based Gene Delivery Systems. Int. J. Pharma Sci. Res., 5 , 812-819

Karkare, S., Chhipa, R., Liu, X., Henry, H., Gasilina, A., Nassar, N., Pauletti, G.M., Ghosh, P.K., and Dasgupta, B. 2014. Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell Cycle Arrest and Suppresses Glioblastoma Growth. Clinical Cancer Res., 20 1, 199-212

Li, H; Han, D; Pauletti, G M; Steckl, A J 2014. Blood Coagulation Screening using a Paper-based Microfluidic Lateral Flow Device Lab Chip, 14 20, 4035-41

Sadat, M.E., Kaveh-Baghbadorani, M., Dunn, A.W., Wagner, H., Ewing, R.C., A.W., Zhang, J., Xu, H., Pauletti, G.M., Mast, D.B., and Shi, D. 2014. Photoluminescence and the Effect of Structure in Fe3O4 Nanoparticles. Appl. Phys. Lett., 105 , 091903

Sadat, M.E., Patel, R., Sookoor, J., Budko, S., Ewing, R.C., Zhang, J., Xu, H., Wang, Y., Pauletti, G.M., Mast, D.B., and Shi, D. 2014. Effect of Spatial Confinement on Magnetic Hyperthermia via Dipolar Interactions in Fe3O4 Nanoparticles for Biomedical Applications. Mater. Sci. Eng. C, 42 , 52-63

Allam, Ayat A; Sadat, Md Ehsan; Potter, Sarah J; Mast, David B; Mohamed, Dina F; Habib, Fawzia S; Pauletti, Giovanni M 2013. Stability and magnetically induced heating behavior of lipid-coated Fe3O4 nanoparticles. Nanoscale research letters, 8 1, 426

Wang, Feng; Pauletti, Giovanni M; Wang, Juntao; Zhang, Jiaming; Ewing, Rodney C; Wang, Yilong; Shi, Donglu 2013. Dual surface-functionalized Janus nanocomposites of polystyrene/Fe?O?@SiO? for simultaneous tumor cell targeting and stimulus-induced drug release. Advanced materials (Deerfield Beach, Fla.), 25 25, 3485-9

Cai, Xiaojun; Dong, Chunyan; Dong, Haiqing; Wang, Gangmin; Pauletti, Giovanni M; Pan, Xiaojing; Wen, Huiyun; Mehl, Isaac; Li, Yongyong; Shi, Donglu 2012. Effective gene delivery using stimulus-responsive catiomer designed with redox-sensitive disulfide and acid-labile imine linkers. Biomacromolecules, 13 4, 1024-34

Basha, S., Vaidhyanathan, S., and Pauletti, G.M. 2011. Selection of Peptide Ligands for Human Placental Transcytosis Systems using in vitro Phage Display Methods Mol. Biol., 716 , 141-156

Basha, Saleem; Vaidhyanathan, Shruthi; Pauletti, Giovanni M 2011. Selection of peptide ligands for human placental transcytosis systems using in vitro phage display. Methods in molecular biology (Clifton, N.J.), 716 , 141-56

Li, Xue-Quan; Wen, Hui-Yun; Dong, Hai-Qing; Xue, Wei-Ming; Pauletti, Giovanni M; Cai, Xiao-Jun; Xia, Wen-Juan; Shi, Donglu; Li, Yong-Yong 2011. Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism. Chemical communications (Cambridge, England), 47 30, 8647-9

Wen, H.Y., Dong, H.Q., Xie, W.J., Li, Y.Y., Wang, K., Pauletti, G.M., and Shi, D. 2011. Rapidly Disassembling Nanomicelles with Disulfide-linked PEG Shell for Glutathione-mediated Intracellular Drug Delivery ChemComm., 47 , 3550-3552

Wen, Hui-Yun; Dong, Hai-Qing; Xie, Wen-juan; Li, Yong-Yong; Wang, Kang; Pauletti, Giovanni M; Shi, Dong-Lu 2011. Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery. Chemical communications (Cambridge, England), 47 12, 3550-2

Cho, H., Dong, Z, Pauletti, G.M., Zhang, J., Xu, H., Gu, H., Wang, L., Ewing, R.C., Huth, Ch., Wang, F., and Shi, D. 2010. Fluorescent Superparamagnetic Nanospheres for Drug Storage, Targeting, and Imaging - A Multifunctional Nanocarrier System for Cancer Diagnosis and Treatment ACS Nano, 4 , 5389-5404

Cho, Hoon-Sung; Dong, Zhongyun; Pauletti, Giovanni M; Zhang, Jiaming; Xu, Hong; Gu, Hongchen; Wang, Lumin; Ewing, Rodney C; Huth, Christopher; Wang, Feng; Shi, Donglu 2010. Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: a multifunctional nanocarrier system for cancer diagnosis and treatment. ACS nano, 4 9, 5398-404

Kawedia, Jitesh D; Jiang, Mengmeng; Kulkarni, Amit; Waechter, Holly E; Matlin, Karl S; Pauletti, Giovanni M; Menon, Anil G 2008. The protein kinase A pathway contributes to Hg2+-induced alterations in phosphorylation and subcellular distribution of occludin associated with increased tight junction permeability of salivary epithelial cell monolayers. The Journal of pharmacology and experimental therapeutics, 326 3, 829-37

Narang, Vishal S; Pauletti, Giovanni M; Gout, Peter W; Buckley, Donna J; Buckley, Arthur R 2007. Sulfasalazine-induced reduction of glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of Doxorubicin. Chemotherapy, 53 3, 210-7

Dixit, Santosh G; Zingarelli, Basilia; Buckley, Donna J; Buckley, Arthur R; Pauletti, Giovanni M 2005. Nitric oxide mediates increased P-glycoprotein activity in interferon-{gamma}-stimulated human intestinal cells. American journal of physiology. Gastrointestinal and liver physiology, 288 3, G533-40

D'Souza, Vanessa M; Buckley, Donna J; Buckley, Arthur R; Pauletti, Giovanni M 2003. Extracellular glucose concentration alters functional activity of the intestinal oligopeptide transporter (PepT-1) in Caco-2 cells. Journal of pharmaceutical sciences, 92 3, 594-603

D'Souza, Vanessa M; Shertzer, Howard G; Menon, Anil G; Pauletti, Giovanni M 2003. High glucose concentration in isotonic media alters caco-2 cell permeability. AAPS pharmSci, 5 3, E24

Plageman, Lauren R; Pauletti, Giovanni M; Skau, Kenneth A 2002. Characterization of acetylcholinesterase in Caco-2 cells. Experimental biology and medicine (Maywood, N.J.), 227 7, 480-6

Gangwar, S; Pauletti, G M; Siahaan, T J; Stella, V J; Borchardt, R T 1999. Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using an acyloxyalkoxy promoiety. Methods in molecular medicine, 23 , 37-51

Gudmundsson, O S; Pauletti, G M; Wang, W; Shan, D; Zhang, H; Wang, B; Borchardt, R T 1999. Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability. Pharmaceutical research, 16 1, 7-15

Sudoh, M; Pauletti, G M; Yao, W; Moser, W; Yokoyama, A; Pasternak, A; Sprengeler, P A; Smith, A B; Hirschmann, R; Borchardt, R T 1998. Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers. Pharmaceutical research, 15 5, 719-25

Okumu, F W; Pauletti, G M; Vander Velde, D G; Siahaan, T J; Borchardt, R T 1997. Effect of restricted conformational flexibility on the permeation of model hexapeptides across Caco-2 cell monolayers. Pharmaceutical research, 14 2, 169-75

Pauletti, G M; Gangwar, S; Wang, B; Borchardt, R T 1997. Esterase-sensitive cyclic prodrugs of peptides: evaluation of a phenylpropionic acid promoiety in a model hexapeptide. Pharmaceutical research, 14 1, 11-7

Pauletti, G M; Okumu, F W; Borchardt, R T 1997. Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway. Pharmaceutical research, 14 2, 164-8

T Borchardt R, ; Jeffrey, ; Siahaan, ; Gangwar, ; Pauletti, 1997. Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies. Advanced drug delivery reviews, 27 2-3, 235-256

Pauletti, G M; Gangwar, S; Okumu, F W; Siahaan, T J; Stella, V J; Borchardt, R T 1996. Esterase-sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide. Pharmaceutical research, 13 11, 1615-23

Huth, Ch., Shi, D., Wang, F., Carrahar, D., Lian, J., Lu, F., Zhang, J., Ewing, R.C., and Pauletti, G.M. . Phospholipid Assembly on Superparamagnetic Nanoparticles for Thermoresponsive Drug Delivery Applications NanoLIFE, ,

Narang, Vishal S; Pauletti, Giovanni M; Gout, Peter W; Buckley, Donna J; Buckley, Arthur R . Suppression of cystine uptake by sulfasalazine inhibits proliferation of human mammary carcinoma cells. Anticancer research, 23 6C, 4571-9

Published Abstracts

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Abd El-Hamid, B.N., Swarnakar, N.K., Soliman, G.M., Shafie, M.A., and Pauletti, G.M. 2016. Encapsulation of Alendronate-Polyethyleneimine Complexes into Nanostructured Lipid Carriers Enhances Intestinal Permeation in vitro. 30th Annual Meeting of the AAPS, , November 13 – 17, Denver, CO (#23T1000) ,

Eleraky, N.E., Swarnakar, N.K., Mohamed, D.F., Attia, M.A., and Pauletti, G.M. 2016. Permeation-enhancing Nanoparticle Formulation to Enable Oral Absorption of Enoxaparin. 30th Annual Meeting of the AAPS, November 13 – 17, Denver, CO (#25R0900) ,

Abd El-Hamid, B.N., Soliman, G.M., Shafie, M.A., and Pauletti, G.M. 2015. Hydrophobic Ion Pairing to Augment Loading Efficiency of Alendronate in Nanostructured Lipid Carriers. 29th Annual Meeting of the AAPS,, October 25 – 29, Orlando, FL (#W4098) ,

Eleraky, N.E., Mohamed, D.F., Attia, M.A., and Pauletti, G.M. 2015. Thermodynamic Analysis of the Interaction between Low Molecular Weight Heparin and Cetyltrimethylammonium Bromide. 29th Annual Meeting of the AAPS, , October 25 – 29, Orlando, FL (#T3109) ,

Potter, S.J., Domoradzki, J.Y., and Pauletti, G.M. 2015. Comparative in vitro Absorption Models to Estimate Dietary Assimilation of Pharmaceuticals in Fish. 29th Annual Meeting of the AAPS, , October 25 – 29, Orlando, FL (#T2006) ,

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