Division of Pharmaceutical Sciences Faculty

Jianxiong Jiang

  • PhD: Auburn University
  • Postdoctoral Fellow: Emory University
  • MS: East China University of Science & Technology

Contact Information
  • Medical Sciences Building 3202
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0514
  • Office 513-558-7813
  • Fax 513-558-3233
  • Email jianxiong.jiang@uc.edu

Peer Reviewed Publications

Display All

Jiang, Jianxiong; Van, Tri Minh; Ganesh, Thota; Dingledine, Raymond 2018. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS chemical neuroscience, 9 4, 699-707

Hartings, Jed A; York, Jonathan; Carroll, Christopher P; Hinzman, Jason M; Mahoney, Eric; Krueger, Bryan; Winkler, Maren K L; Major, Sebastian; Horst, Viktor; Jahnke, Paul; Woitzik, Johannes; Kola, Vasilis; Du, Yifeng; Hagen, Matthew; Jiang, Jianxiong; Dreier, Jens P 2017. Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction. Brain, 140 10, 2673-2690

Jiang, Jianxiong; Qiu, Jiange; Li, Qianqian; Shi, Zhi 2017. Prostaglandin E2 Signaling: Alternative Target for Glioblastoma? Trends in cancer, 3 2, 75-78

Kang, Xu; Qiu, Jiange; Li, Qianqian; Bell, Katherine A; Du, Yifeng; Jung, Da Woon; Lee, Jae Yeol; Hao, Jiukuan; Jiang, Jianxiong 2017. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Scientific reports, 7 1, 9459

Qiu, Jiange; Shi, Zhi; Jiang, Jianxiong 2017. Cyclooxygenase-2 in glioblastoma multiforme Drug discovery today, 22 1, 148-156

Dey, Avijit; Kang, Xu; Qiu, Jiange; Du, Yifeng; Jiang, Jianxiong 2016. Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside. Trends in pharmacological sciences, 37 6, 463-84

Du, Yifeng; Kemper, Timothy; Qiu, Jiange; Jiang, Jianxiong 2016. Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus. Expert review of neurotherapeutics, 16 2, 123-30

Du, Yifeng; Seibenhener, Michael L; Yan, Jin; Jiang, Jianxiong; Wooten, Michael C 2015. aPKC phosphorylation of HDAC6 results in increased deacetylation activity. PloS one, 10 4, e0123191

Fu, Yujiao; Yang, Myung-Soon; Jiang, Jianxiong; Ganesh, Thota; Joe, Eunhye; Dingledine, Raymond 2015. EP2 Receptor Signaling Regulates Microglia Death. Molecular pharmacology, 88 1, 161-70

Jiang, Jianxiong; Yang, Myung-soon; Quan, Yi; Gueorguieva, Paoula; Ganesh, Thota; Dingledine, Raymond 2015. Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus. Neurobiology of disease, 76 , 126-36

Varvel, Nicholas H; Jiang, Jianxiong; Dingledine, Raymond 2015. Candidate drug targets for prevention or modification of epilepsy. Annual review of pharmacology and toxicology, 55 , 229-47

Ganesh, Thota; Jiang, Jianxiong; Dingledine, Ray 2014. Development of second generation EP2 antagonists with high selectivity. European journal of medicinal chemistry, 82 , 521-35

Ganesh, Thota; Jiang, Jianxiong; Yang, Myung-Soon; Dingledine, Ray 2014. Lead optimization studies of cinnamic amide EP2 antagonists. Journal of medicinal chemistry, 57 10, 4173-84

Rojas, Asheebo; Jiang, Jianxiong; Ganesh, Thota; Yang, Myung-Soon; Lelutiu, Nadia; Gueorguieva, Paoula; Dingledine, Raymond 2014. Cyclooxygenase-2 in epilepsy. Epilepsia, 55 1, 17-25

Ganesh, Thota; Jiang, Jianxiong; Shashidharamurthy, Rangaiah; Dingledine, Ray 2013. Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists. ACS medicinal chemistry letters, 4 7, 616-621

Jiang, Jianxiong; Dingledine, Ray 2013. Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection. Trends in pharmacological sciences, 34 7, 413-23

Jiang, Jianxiong; Dingledine, Ray 2013. Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. The Journal of pharmacology and experimental therapeutics, 344 2, 360-7

Jiang, Jianxiong; Quan, Yi; Ganesh, Thota; Pouliot, Wendy A; Dudek, F Edward; Dingledine, Raymond 2013. Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Proceedings of the National Academy of Sciences of the United States of America, 110 9, 3591-6

Quan, Yi; Jiang, Jianxiong; Dingledine, Ray 2013. EP2 receptor signaling pathways regulate classical activation of microglia. The Journal of biological chemistry, 288 13, 9293-302

Seibenhener, M Lamar; Zhao, Ting; Du, Yifeng; Calderilla-Barbosa, Luis; Yan, Jin; Jiang, Jianxiong; Wooten, Marie W; Wooten, Michael C 2013. Behavioral effects of SQSTM1/p62 overexpression in mice: support for a mitochondrial role in depression and anxiety. Behavioural brain research, 248 , 94-103

Yan, Jin; Seibenhener, Michael Lamar; Calderilla-Barbosa, Luis; Diaz-Meco, Maria-Theresa; Moscat, Jorge; Jiang, Jianxiong; Wooten, Marie W; Wooten, Michael C 2013. SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. PloS one, 8 9, e76016

Jiang, Jianxiong; Ganesh, Thota; Du, Yuhong; Quan, Yi; Serrano, Geidy; Qui, Min; Speigel, Iris; Rojas, Asheebo; Lelutiu, Nadia; Dingledine, Raymond 2012. Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Proceedings of the National Academy of Sciences of the United States of America, 109 8, 3149-54

Jiang, Jianxiong; Ganesh, Thota; Du, Yuhong; Thepchatri, Pahk; Rojas, Asheebo; Lewis, Iestyn; Kurtkaya, Serdar; Li, Lian; Qui, Min; Serrano, Geidy; Shaw, Renee; Sun, Aiming; Dingledine, Ray 2010. Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor. Proceedings of the National Academy of Sciences of the United States of America, 107 5, 2307-12

Jiang, Jianxiong; Parameshwaran, Kodeeswaran; Seibenhener, M Lamar; Kang, Myoung-Goo; Suppiramaniam, Vishnu; Huganir, Richard L; Diaz-Meco, Maria T; Wooten, Marie W 2009. AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62. Hippocampus, 19 4, 392-406

Jadhav, Trafina; Geetha, Thangiah; Jiang, Jianxiong; Wooten, Marie W 2008. Identification of a consensus site for TRAF6/p62 polyubiquitination. Biochemical and biophysical research communications, 371 3, 521-4

Jiang, Jianxiong; Suppiramaniam, Vishnu; Wooten, Marie W 2007. Posttranslational modifications and receptor-associated proteins in AMPA receptor trafficking and synaptic plasticity. Neuro-Signals, 15 5, 266-82

Geetha, Thangiah; Jiang, Jianxiong; Wooten, Marie W 2005. Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Molecular cell, 20 2, 301-12

Visit the College

Group Photo of the dean and students

See our difference at the James L Winkle College of Pharmacy. We are among the oldest in the nation, with cutting-edge research, excellent scholarship and distinguished faculty. Visit the College to Learn More

Life in Cincinnati

Resting along the banks of the Ohio River, Cincinnati offers something for everyone. From foodies to sports fans, cultural hotspots to family-friendly attractions discover our dynamic city. Learn More about Life in Cincinnati

Photo of a statue