Kumari Laboratory

Kumari Lab

Our research specialty is in the area of complex fluids, nanotechnology, microfluidics, neutron scattering and drug delivery. We combine experimental and theoretical approaches to develop novel nano-architectures with applications in the areas of sustainability, green chemistry, pharmaceuticals/drug encapsulation and delivery, surfactant and formulation science, gas sorption and material science.

Headshot of Harshita Kumari

Harshita Kumari

Associate Professor, Pharmacy Kumari Lab

3109 C Medical Sciences Building

513-558-1872

Harshita Kumari is an Associate Professor in the Division of Pharmaceutical Sciences at the University of Cincinnati. Dr. Kumari’s work in the area of solution chemistry of supramolecular complexes is widely recognized. Her current research focuses on integrating principles of modern biophysics into material and formulation science towards the development of novel skin care, oral care, and hair care products. Her research projects focus on understanding mechanisms of delivery and deposition of actives onto the skin/hair and elucidating the parameters to control them. In addition, her research focuses on developing methods to construct novel nanometric delivery vehicles, based on the principles of self-assembly and molecular recognition. Her work is published in several peer-reviewed journals. 
Headshot of Chandra Adeola Ade-Brown

Chandra Adeola Ade-Brown

Headshot of Marzieh Susanna Mirzamani

Marzieh Susanna Mirzamani

Post Doc Fellow, Pharmacy Kumari Lab

Medical Sciences Building

513-558-3784

Headshot of Jinnipha   Pajoubpong

Jinnipha Pajoubpong

Graduate Assistant, Pharmacy Kumari Lab

Headshot of Arnab Dawn

Arnab Dawn

Research Associate, Pharmacy Kumari Lab

2202 Medical Sciences Building

513-558-1817

Headshot of Suchitra Dilipkumar Panigrahi

Suchitra Dilipkumar Panigrahi

Graduate Assistant, Pharmacy Kumari Lab

Headshot of Priyanka Mishra

Priyanka Mishra

Headshot of Noura Hassan Abd Ellah

Noura Hassan Abd Ellah

Supramolecular Chemistry

Supramolecular Chemistry

Our research focuses on synthesizing novel cavitands, and their complexes with metal, photoactives, and drugs. Preorganization of cavitands in a bowl shape with upper- and lower-rim functionality, offers a favorable environment for guest interaction and inclusion.  In particular, we are interested in rationalizing the principles of self-assembly, templation and nucleation, through combined solid and solution phase studies.  

Complex Fluids

Complex Fluids

The mobility and involvement of solvent molecules are different in crystals and in gels. We are particularly interested in studying the nucleation and equilibriums involved in the following hierarchical assembly processes:

  • One-dimensional growth of gel fiber
  • Crystallization of nano-assemblies in space (three-dimensional growth)
  • Binary nucleation process in a supramolecular gel phase crystallization (multi-dimensional grwoth)

Neutron Scattering

Neutron Scattering

We utilize small angle neutron scattering (SANS) technique to study the size and shape of self assembled systems (colloid, microemulsion, fibrillar assembly, metal nanocapsule, polymer), in solution.

Also, we use neutron reflectometry technique to estimate the penetration of an active in free state and in complexed (to our synthesized host) state into a model skin membrane.

Crystal Engineering

Crystal Engineering

In our group, we exploit the principles of Crystal Engineering to design new functional materials. In particular, we are interested in the encapsulation of photoactives and active ingredient compounds by non-covalent molecular assemblies. This includes capture of substrates in molecular nanocapsules or nanotubules assembled by means of hydrogen bonding or non-covalent interactions.

Soft Multiporous Framework

Soft Multiporous Framework

We aim to exploit macrocycle-derived supramolecular gel network as an inexpensive, synthetically tuneable and efficient, multiporous system for selective gas sorption and separation.

Cosmetic Science

Soft Multiporous Framework

o develop cosmetics that are safe and effective on human skin, manufacturers must have a deep understanding and knowledge of the chemistry involved in the formulations and their mechanisms of action. Our research focuses on integrating principles of modern biophysics into materials that would define the next generation of this field. We assess structure-property relationships to develop novel skin care, oral care and hair care products. In addition, we probe into mechanisms of delivery and deposition actives onto the skin/hair and elucidate the parameters to control them. We construct novel nanometric delivery vehicles, based on the principles of self-assembly and molecular recognition.

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51. Ade-Browne, C.; Dawn, A.; Mirzamani, M.; Qian, S; Kumari, H. “Differential Behaviors of Sodium laurylsulfate Micelles in the Presence of Nonionic Polymers” J. Colloid & Interface Sci. In Press. DOI: 10.1016/j.jcis.2019.02.081

50. Dawn, A.; Mirzamani, M.; Jones, C. D.; Yufit, D. S.; Qian, S.; Steed, J. W.; Kumari, H. “Investigating the effect of supramolecular gel phase crystallization on gel nucleation” Soft Matter 2018,14, 9489-9497.

49. Irene Ling, Harshita Kumari, Marzieh Mirzamani, Alexander N. Sobolev, Christopher Garvey, Jerry L. Atwood, Colin L. Raston. Phase dependent structural perturbation of a robust multicomponent icosahedral array. Axially distortable multiple component assembled icosahedra. Chem. Commun. 2018, 54, 10824-10827.

48. Harshita Kumari, Arnab Dawn, Charles L. Barnes. Effect of varying bases on preferential crystallization of C-methylresorcin[4]arene and calix[6]arene. Supramol. Chem. 2018, 30, 970-975.

47. Arnab Dawn, Andrew Eisenhart, Marzieh Mirzamani, Thomas L. Beck, Harshita Kumari. Bowl-in-bowl complex formation with mixed sized calixarenes: Adaptivity towards guest binding. Chem. Comm. 2018. 54, 7131-7134.

46. Hunani M. Thomas, Harshita Kumari,Julia Maddalena, Collin M. Mayhan, Lindsey T. Ellis, John E. Adams, Carol A. Deakyne. Conformational Preference and Dynamics of Pyrogallol[4]arene: Stability, Interconversion, and Solvent Influence. Supramol. Chem. 2018, 30, 520-532.

45. Arnab Dawn and Harshita Kumari. Low Molecular Weight Gels Under Shear: Rheology as the Tool for Elucidating Structure-Function Correlation. Chem. Eur. J. 2017, 24 (4), 762-776.

44. Arnab Dawn, Harish Chandra, Chandra Ade-Brown, Jagjit Yadav, Harshita Kumari. Multifaceted Supramolecular Interactions from C-methylresorcin[4]arene lead to an enhancement in in-vitro antibacterial activity of gatifloxacin. Chem. Eur. J.2017, 23 (72) 18172-18179. 

43. Amanda M. Drachnik, Harshita Kumari, Collin M. Mayhan, Drew A. Fowler, Wei. G. Wycoff, Charles L. Barnes, John E. Adams, Carol A. Deakyne, Jerry L. Atwood.  Conversion of Pregabalin to 4-Isobutylpyrrolidone-2. J. Pharm. Sci..2017, 106(10), 3095-3102. 

42. Harshita Kumari and Jerry L. Atwood. “Pyrogallol[4]arenes in self-assembly” Comprehensive Supramolecular Chemistry II. Elsevier, Oxford 2017. DOI: 10.1016/B978-0-12-409547-2.12580-6. In book: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

41. Harshita Kumari. “Small-angle Neutron Scattering in Supramolecular Complexes” Comprehensive Supramolecular Chemistry II. Elsevier, Oxford 2017. DOI: 10.1016/B978-0-12-409547- 2.12491-6. In book: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

40. Harshita Kumariand Jerry L. Atwood. “Calixarene in Solid State.” Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, Oxford, 2017. DOI: 10.1016/B978- 0-12-409547-2.11094-7.

39. Harshita Kumariand Jerry L. Atwood. “Metallosupramolecular assemblies in solution” Comprehensive Supramolecular Chemistry II. Elsevier, Oxford 2017. DOI: 10.1016/B978-0-12-409547-2.12596-X · In book: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

38. Harshita Kumari, Carol A. Deakyne, Jerry L. Atwood. “Macrocyclic Coordination Chemistry of Resorcin[4]arenes and Pyrogaloll[4]arenes.” Macrocyclic and Supramolecular Chemistry:  How Izatt-Christensen Award Winners Shaped the Field, John Wiley & Sons, Indianapolis, 2016, 325-342. ISBN 9781119053866 (epub).

37. Collin M. Mayhan, Amanda M. Drachnik, Andrew V. Mossine,Harshita Kumari, John E. Adams, Jerry L. Atwood, Carol A. Deakyne. Metal organic nanocapsules as two-dimensional network building blocks.  J. Phys. Chem. - C 2016, 120 (24) 13159-13168.

36. Harshita Kumari, Charles L. Barnes, Carol A. Deakyne, Jerry L. Atwood. Metal exchange study of pyrogallol[4]arene based nanocapsules. Invited articlefor CrystEngComm themed issue on Form and function of molecular cups and capsules, 2016, 18(26), 4909-4913. 

35. Kasturi Vimalanathan, Jason R. Gascooke, Irene Suarez-Martinez, Nigel Marks, Harshita Kumari, Christopher J. Garvey, Jerry L. Atwood, Warren D. Lawrance, and Colin L. Raston. Fluid dynamic laterally slicing of high tensile strength carbon nanotubes. Scientific Reports.Sept 2016, 6, 22865.

34. Harshita Kumari, Steven R. Kline, Stuart R. Kennedy, Christopher Garvey, Colin L. Raston, JerryL. Atwood, Jonathan W. Steed. Manipulating three-dimensional gel network entanglement by thin film shearing.Chem. Commun.2016,52,4513 – 4516.

33. Harshita Kumari, Sarah E. Armitage, Steven R. Kline, Krishna K. Damodaran, Stuart R. Kennedy, Jerry L. Atwood, Jonathan W. Steed. Fluorous ‘ponytails’ lead to strong gelators showing thermally induced structure evolution. Soft Matter. 2015, 11(43), 8471-8478. 

32. Rahul S. Patil, Amanda M. Drachik,Harshita Kumari, Charles L. Barnes, Carol A. Deakyne, Jerry L. Atwood. Solvent Induced Manipulation of Supramolecular Organic Frameworks. Cryst. Growth & Des.2015, 15(6), 2781-2786.

31. Rahul S. Patil,Harshita Kumari, Charles L. Barnes, Jerry L. Atwood. Anion- and Spacer-directed host-guest complexes of bipyridine with pyrogallol[4]arene. Chem.-Eur. J.2015, 21(29), 10431-10435.

30. Rahul S. Patil,Harshita Kumari, Charles L. Barnes, Jerry L. Atwood. Engineering Supramolecular Organic Frameworks (SOFs) of C-alkylPyrogallol[4]arene with Bipyridine-based Spacers. Chem. Commun. 2015, 51(12), 2304-2307.

29. Harshita Kumari, Ping Jin, Scott Dalgarno, Simon Teat, Jerry L. Atwood. Strong cation Lπ interactions cause the imprisonment of thallium ions within pyrogallol[4]arene nanocapsules. J. Am. Chem Soc. 2014, 136(49), 17002-17005.

28. Harshita Kumari, Carol A. Deakyne and Jerry L. Atwood. Solution structures of nanoassemblies based on pyrogallol[4]arenes.Acc. Chem. Res. 2014, 47(10), 3080-3088.

27. Harshita Kumari, Ping Jin, Simon J. Teat, Charles L. Barnes, Scott J. Dalgarno, and Jerry L. Atwood. Entrapment of elusive guests within metal-seamed nanocapsules. Angew. Chemie.2014, 53(48), 13088-13092.

26. Harshita Kumari, Steven R. Kline and Jerry L. Atwood. Aqueous solubilization of hydrophobic supramolecular metal-seamed organic nanocapsules. Chem. Sci.2014, 2554-2559. 

25. Harshita Kumari, Steven R. Kline, Drew A. Fowler, Andrew V. Mossine, Carol A. Deakyne and Jerry L. Atwood. Solution Superstructures: Truncated Cubeoctahedron Structures of Pyrogallol[4]arene Nanoassemblies. Chem. Commun.2014, 50,109-111. 

24. Harshita Kumari, Andrew V. Mossine, Nathaniel J. Schuster, Charles L. Barnes, Carol A. Deakyne and Jerry L. Atwood. Packing Arrangement ofC-alkylpyrogallol[4]arene Nanocapsules with Varying Chain LengthsCrystEngComm. 2014, 16, 3718-3721.  Invited articlein contribution to the CrystEngComm themed issue on Structural Macrocyclic Supramolecular Chemistry. 

23. Ping Jin,Harshita Kumari, Stuart J. Kennedy, Charles L. Barnes, Simon J. Teat, Scott J. Dalgarno, Jerry L. Atwood. (2014). Structural alteration of the metal-organic pyrogallol[4]arene nano-capsule motif by incorporation of large metal centers.Chem. Commun.2014,50, 4508-4510.

22. Amanda Drachnik, Harshita Kumari, Charles L. Barnes, Carol A. Deakyne, Jerry L. Atwood. Encapsulation of manganese and cobalt complexes within resorcin[4]arene dimers.CrystEngCommun.2014, 16, 7172-7175. 

21. Collin M. Mayhan,Harshita Kumari, Elizabeth M. McClure, Joel F. Leibman and Carol A. Deakyne. Proton affinity and gas-phase basicity of hydroquinol: a computation study. J. Chem. Thermodyn.  2014, 73, 171-177.Invited articlefor a special issue. 

20. Rahul S. Patil, Andrew V. Mossine,Harshita Kumari, Charles L. Barnes and Jerry L. Atwood. Engineering void space enclosed within resorcin[4]arene-based supramolecular frameworks. In Press.Cryst. Growth and Des. 2014, 14(10), 5212-5218.Invitedcontributionfor special issue of 2014 International Year of Crystallography (IYCr 2014). 

19. Harshita Kumari, Loredana Erra, Alicia C. Webb, Prashant Bhatt, Charles Barnes, John E. Adams, Carol A. Deakyne, Leonard J. Barbour and Jerry L. Atwood. Pyrogallol[4]arenes as frustrated organic solids.J. Am. Chem. Soc.  2013, 135 (45), 16963–16967.

18. Harshita Kumari, Agneiszka Janiak, Carol A. Deakyne, Jerry L. Atwood. Pyrogallol[4]arenes: A class of calixarenes with novel structures and gas sorption properties. In Press.2013. Invited articlein contribution to the Seventh International Conference on Materials Engineering for Resources.

17. Harshita Kumari, Alison Good, Vincent Smith, Leonard J. Barbour, Carol A. Deakyne and Jerry L. Atwood.18-crown-6 templates offset linked pyroagllol[4]arene dimers. 2013, 25 (9-11), 591-59.5Supramol. ChemInvited contributionfor a Special Issue in Supramolecular Chemistry in honor of Rocco Ungaro.

16. Drew A. Fowler, Asanka Rathnayake, Stuart Kennedy, Harshita Kumari, Christine Beavers, Simon J. Teat and Jerry L. Atwood. Introducing defects into metal-seamed nanocapsules using mixed-macrocycles. J. Am. Chem. Soc.2013, 135 (33), 12184–12187.

15. Harshita Kumari, Cindi L. Dennis, Andrew V. Mossine and Jerry L. Atwood. Magnetic differentiation of pyrogallol[4]arene tubular and capsular frameworks. J. Am. Chem. Soc.2013, 135 (19), 7110–7113. 

14. Harshita Kumari, Jin Zhang, Loredana Erra, Leonard J. Barbour, Carol A. Deakyne and Jerry L. Atwood. (2013). Cocrystals of gabapentin withC-alkylresorcin[4]arenes.CrystEngCommun; 2013, 15, 4045-4048.  

13. Harshita Kumari, Ping Jin, Carol A. Deakyne and Jerry L. Atwood. Metal ion transport across metal-organic nanocapsules. Invited review articlefor a special issue on Nanoreactors and Molecular Prisons, Curr. Org. Chem.2013, 17, 1481-1488. 

12. Harshita Kumari, Steven R. Kline, and Jerry L. Atwood. Investigating structural alterations in pyrogallol[4]arene-pyrene nanotubular frameworks.SMALL Journal2012, 8 (21), 3321-3325. 

11. Harshita Kumari, Steven R. Kline, Cindi L. Dennis, Andrew V. Mossine, Rick L. Paul, Carol A. Deakyne and Jerry L. Atwood. Solution-phase and magnetic approach towards understanding iron gall inks. Angew. Chemie.2012, 51 (37), 9263-9266. Front Cover Illustration 

10. Andrew V. Mossine, Harshita Kumari, Drew A. Fowler, Anine Shih, Steven R. Kline, Charles L. Barnes, and Jerry L. Atwood. Ferrocene species within pyrogallol[4]arenes tubes. Chem.-Eur. J.2012, 18 (33), 10258–10260. 

9. Harshita Kumari, Steven R. Kline, Wei G. Wycoff, Andrew V. Mossine, Rick L. Paul,  Carol A. Deakyne and Jerry L. Atwood. Solution-phase structures of gallium-containing pyrogallol[4]arene scaffolds. Angew.Chemie.2012, 51 (21), 5086-5091. Frontispiece Illustration

8. Harshita Kumari, Steven R. Kline, and Jerry L. Atwood. Investigating of insulin templation byC-methylresorcin[4]arenes.Chem.Commun. 2012, 48 (30), 3599. 

7. Harshita Kumari, Andrew V. Mossine, Steven R. Kline, Cindi L. Dennis, Drew A. Fowler, Simon J. Teat, Charles L. Barnes, Carol A. Deakyne, and Jerry L. Atwood. Controlling the self-assembly of metal-seamed organic nanocapsules. Angew. Chemie.2012, 51 (6), 1452-1454. 

6. Harshita Kumari, Cindi L. Dennis, Steve R. Kline, Andrew V. Mossine, Carol A. Deakyne and Jerry L. Atwood. Exploring magnetic behavior of nickel coordinated pyrogallol[4]arene nanocapsules. ACS Nano, 2012, 6 (1), 272-275. 

5. Andrew V. Mossine, Harshita Kumari, Drew A. Fowler, Annie Shih, Steven R. Kline, Charles L. Barnes and Jerry L. Atwood. Ferrocene as a hydrophobic templating agent with pyrogallol[4]arenes. Isr. J. Chem., 2011, 51(7), 840-842.

4. Harshita Kumari, Steven R. Kline, Nathaniel J. Schuster, Jerry L. Atwood. Solution Structure of Copper-seamed C-alkylpyrogallol[4]arene Nanocapsules with Varying Chain Lengths. Chem. Commun.2011, 47(45), 12298-12300. 

3. Harshita Kumari, Steven R. Kline, Nathaniel J. Schuster, Charles L. Barnes and Jerry L. Atwood. Exploring the Ellipsoidal and Core-Shell Geometries of Copper-seamed C-alkylpyrogallol[4]arene Nanocapsules in Solution.J. Am. Chem. Soc. 2011, 133 (45), 18102–18105. 

2. Andrew Maerz,Drew A. Fowler, Andrew V. Mossine,Miten Mistry, Harshita Kumari, Charles L. Barnes, Carol A. Deakyne, Jerry L. Atwood. (2011). Solvent Mediated Self-Assembly of Organic Nanostructures. New J. Chem., 2011, 35(4), 784-787. 

1. Rekha Navada, Harshita Kumari, S Le, and J. Zangh. Oral malodor reduction from a zinc-containing toothpaste. J. Clinical Dentistry,2008, 19(2), 69-73.